{"id":58386,"date":"2023-07-07T06:23:35","date_gmt":"2023-07-07T06:23:35","guid":{"rendered":"https:\/\/purmabiologics.com\/blog\/?post_type=product&#038;p=58386"},"modified":"2026-08-18T14:40:01","modified_gmt":"2026-08-18T20:40:01","slug":"premium-fetal-bovine-serum-p-fbs","status":"publish","type":"product","link":"https:\/\/purmabiologics.com\/blog\/product\/premium-fetal-bovine-serum-p-fbs\/","title":{"rendered":"PurMa\u2122 Fetal Bovine Serum (FBS)"},"content":{"rendered":"<h2 data-rm-block-id=\"block-1\">What Is Fetal Bovine Serum (FBS)?<\/h2>\n<p data-rm-block-id=\"block-2\">PurMa Biologics&#8217; Fetal Bovine Serum (FBS) is a USA-sourced, research-grade serum derived from bovine fetal blood, supplying the undefined growth factors and nutrients cell culture laboratories rely on to grow mammalian and other eukaryotic cell lines. Every lot is gamma irradiated, heat inactivated, and tested for sterility, endotoxin, and a full virus panel, including Bovine Viral Diarrhea Virus and Bovine Parvovirus, before it ships.<\/p>\n<p>Not sure which serum fits your cells? See our complete guide to\u00a0<a href=\"\/cell-culture-serum\/\">cell culture serum.<\/a><\/p>\n<p>Comparing FBS specifically to Horse Serum? See our <a href=\"https:\/\/purmabiologics.com\/blog\/horse-serum-vs-fbs\/\">head-to-head comparison.<\/a><\/p>\n<p data-rm-block-id=\"block-3\"><strong>Our Serum Products<\/strong><\/p>\n<p data-rm-block-id=\"block-4\">PurMa Biologics produces seven types of fetal bovine serums. The three following are considered premium:<\/p>\n<ol>\n<li data-rm-block-id=\"block-5\">PurMa \u2122Premium Fetal Bovine Serum (P-FBS).<\/li>\n<li data-rm-block-id=\"block-6\">PurMa\u2122 Ultra-Premium Fetal Bovine Serum (UP-FBS).<\/li>\n<li data-rm-block-id=\"block-7\">PurMa\u2122 Endotoxin Depleted Fetal Bovine Serum (EDP-FBS).<\/li>\n<\/ol>\n<p data-rm-block-id=\"block-8\"><strong><span style=\"color: #000000;\">PurMa\u2122Premium FBS<\/span><\/strong><\/p>\n<ul>\n<li data-rm-block-id=\"block-9\">All three PurMa<sup>TM <\/sup>Premium FBS are of USA origin.<\/li>\n<li data-rm-block-id=\"block-10\">Have been gamma irradiated,<\/li>\n<li data-rm-block-id=\"block-11\">Have been heat inactivated.<\/li>\n<li data-rm-block-id=\"block-12\">Have been vigorously analyzed with the certificate of analysis.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p data-rm-block-id=\"block-13\"><strong>The major differences between P-FBS and UP-FBS<\/strong><\/p>\n<ul>\n<li data-rm-block-id=\"block-14\">The source of the Blood and therefore:<\/li>\n<li data-rm-block-id=\"block-15\">Significantly higher growth by UP-FBS compared to P-FBS<\/li>\n<li data-rm-block-id=\"block-16\">The depth of the analysis<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p data-rm-block-id=\"block-17\"><strong>Content of PurMa\u2122 Premium Fetal Bovine Serum (P-FBS)<\/strong><\/p>\n<p data-rm-block-id=\"block-18\">Over the years, we have tested and analyzed\u00a0 fetal bovine serum premium and generated our own proprietary method for separating serum from other components of the blood as well as purifying final products from raw materials. Please see the below table. We routinely test every Lot ordered. We seriously look at the following criteria: IgG, Total Protein, Iron, Percent Iron Saturation, Inorganic Phosphorus, Glucose, Alkaline Phosphatase,\u00a0 Potassium, Albumin, Blood Urea Nitrogen, Sodium, Calcium, Chloride, Total Bilirubin, Creatinine, Gamma Globulin, , Lactate Dehydrogenase, TIBC, SGOT, SGPT.<\/p>\n<p data-rm-block-id=\"block-19\"><strong>PurMa Biologics Performs Deep Analysis<\/strong><\/p>\n<p data-rm-block-id=\"block-20\">Evaluated parameters help with adjusting various elements, and as a result, the consistency of analysis among various Lots will greatly improve.<\/p>\n<p data-rm-block-id=\"block-21\">Consistency of the ingredients among different Lots.<\/p>\n<p data-rm-block-id=\"block-22\">Purifying the serum with this high stringency and robustness of the processes will make the content of serum less variable.<\/p>\n<h4 data-rm-block-id=\"block-23\">Analysis<\/h4>\n<p data-rm-block-id=\"block-24\">Click here for the detail analysis:<strong><a href=\"https:\/\/purmabiologics.com\/blog\/wp-content\/uploads\/2023\/07\/Routin-Patalogicsl-Analysis-on-PurMa-Bovine-and-Horse-Serums.pdf\"><span style=\"color: #0000ff;\">Routine Pathological Analysis on PurMa Bovine and Horse Serums<\/span><\/a><\/strong><\/p>\n<h5 data-rm-block-id=\"block-25\">References:<\/h5>\n<ol>\n<li data-rm-block-id=\"block-26\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7421602\/\" rel=\"nofollow noopener\" target=\"_blank\"><span style=\"color: #0000ff;\">The preparation of antigenic hapten-carrier conjugates: a survey. <\/span><\/a>Erlanger BF. Methods Enzymol. 1980;70(A):85-104. doi: 10.1016\/s0076-6879(80)70043-5. PMID:<\/li>\n<li data-rm-block-id=\"block-27\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10775159\/\" rel=\"nofollow noopener\" target=\"_blank\"><span style=\"color: #0000ff;\">Development rates of male bovine nuclear transfer embryos derived from adult and fetal cells. <\/span><\/a>Hill et al. 2000 May;62(5):1135-40. doi: 10.1095\/biolreprod62.5.1135. PMID: 10775159.<\/li>\n<li data-rm-block-id=\"block-28\"><span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20362047\/\" rel=\"nofollow noopener\" target=\"_blank\">Optimization of chemically defined cell culture media&#8211;replacing fetal bovine serum in mammalian in vitro methods. <\/a><\/span>van der Valk et al. Toxicol In Vitro. 2010 Jun;24(4):1053-63. doi: 10.1016\/j.tiv.2010.03.016. Epub 2010 Mar 31. PMID: 2036204.<\/li>\n<\/ol>\n<table width=\"708\">\n<tbody>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-29\"><strong>Methodology<\/strong><\/td>\n<td width=\"120\" data-rm-block-id=\"block-30\"><strong>Unit measured<\/strong><\/td>\n<td width=\"108\" data-rm-block-id=\"block-31\"><strong>Accepted level<\/strong><\/td>\n<td width=\"114\" data-rm-block-id=\"block-32\"><strong>Result<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-33\">Sterility (Current USP and EP 2.6.1 for Bacteria &amp; Fungi)<\/td>\n<td width=\"120\" data-rm-block-id=\"block-34\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-35\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-36\">Not Detected<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-37\">pH<\/td>\n<td width=\"120\" data-rm-block-id=\"block-38\">N\/A<\/td>\n<td width=\"108\" data-rm-block-id=\"block-39\">measured<\/td>\n<td width=\"114\" data-rm-block-id=\"block-40\">6.58<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-41\">Osmolality (USP 785)\u00a0\u00a0\u00a0\u00a0 mOsm\/KgH2<\/td>\n<td width=\"120\" data-rm-block-id=\"block-42\">mOsm\/KgH20<\/td>\n<td width=\"108\" data-rm-block-id=\"block-43\">280-340<\/td>\n<td width=\"114\" data-rm-block-id=\"block-44\">288<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-45\">Hemoglobin (Fleming &amp; Woolf)<\/td>\n<td width=\"120\" data-rm-block-id=\"block-46\">mg\/dL<\/td>\n<td width=\"108\" data-rm-block-id=\"block-47\">&lt;25<\/td>\n<td width=\"114\" data-rm-block-id=\"block-48\">12.9<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-49\">Endotoxin (USP 85)<\/td>\n<td width=\"120\" data-rm-block-id=\"block-50\">EU\/mL<\/td>\n<td width=\"108\" data-rm-block-id=\"block-51\">&lt;2.0<\/td>\n<td width=\"114\" data-rm-block-id=\"block-52\">&lt;0.100<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-53\">Mycoplasma (Barile &amp; Kern; Large Volume, Direct Culture)<\/td>\n<td width=\"120\" data-rm-block-id=\"block-54\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-55\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-56\">Not Detected<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-57\">IgG<\/td>\n<td width=\"120\" data-rm-block-id=\"block-58\">Elliza<\/td>\n<td width=\"108\" data-rm-block-id=\"block-59\">Measured<\/td>\n<td width=\"114\" data-rm-block-id=\"block-60\">0.19 ug\/ml<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-61\">Albumin<\/td>\n<td width=\"120\" data-rm-block-id=\"block-62\">Eliza<\/td>\n<td width=\"108\" data-rm-block-id=\"block-63\">Measured<\/td>\n<td width=\"114\" data-rm-block-id=\"block-64\">\u2264 4.6 g\/dL<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-65\"><strong>Virus Testing (9 CFR 113.53c)<\/strong><\/td>\n<td width=\"120\" data-rm-block-id=\"block-66\"><\/td>\n<td width=\"108\" data-rm-block-id=\"block-67\"><\/td>\n<td width=\"114\" data-rm-block-id=\"block-68\"><\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-69\">Bovine Adenovirus<\/td>\n<td width=\"120\" data-rm-block-id=\"block-70\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-71\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-72\">Not Detected<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-73\">Bovine Parvovirus<\/td>\n<td width=\"120\" data-rm-block-id=\"block-74\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-75\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-76\">Not Detected<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-77\">Bovine Respiratory Syncytial Virus<\/td>\n<td width=\"120\" data-rm-block-id=\"block-78\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-79\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-80\">Not Detected<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-81\">Bovine Viral Diarrhea Virus<\/td>\n<td width=\"120\" data-rm-block-id=\"block-82\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-83\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-84\">Not Detected<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-85\">Rabies<\/td>\n<td width=\"120\" data-rm-block-id=\"block-86\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-87\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-88\">Not Detected<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-89\">Reovirus<\/td>\n<td width=\"120\" data-rm-block-id=\"block-90\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-91\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-92\">Not Detected<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-93\">Cytopathogenic Agents (IBR)<\/td>\n<td width=\"120\" data-rm-block-id=\"block-94\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-95\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-96\">Not Detected<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-97\">Hemadsorbing Agents (PI3)<\/td>\n<td width=\"120\" data-rm-block-id=\"block-98\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-99\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-100\">Not Detected<\/td>\n<\/tr>\n<tr>\n<td width=\"366\" data-rm-block-id=\"block-101\">Bluetongue<\/td>\n<td width=\"120\" data-rm-block-id=\"block-102\">NA<\/td>\n<td width=\"108\" data-rm-block-id=\"block-103\">Not Detected<\/td>\n<td width=\"114\" data-rm-block-id=\"block-104\">Not Detected<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p data-rm-block-id=\"block-105\">\n<p><strong>Learn more:<\/strong> <a href=\"\/what-is-fetal-bovine-serum-used-for\/\">What Is Fetal Bovine Serum Used For?<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>USA-sourced, research-grade Fetal Bovine Serum (P-FBS) that supplies the undefined growth factors and nutrients mammalian and other eukaryotic cell lines rely on.<\/p>\n<ul>\n<li>Made in the USA from bovine fetal blood; gamma irradiated and heat inactivated<\/li>\n<li>Every lot tested for sterility, endotoxin, and a full virus panel, with a Certificate of Analysis<\/li>\n<li>Available in three premium grades: Premium (P-FBS), Ultra-Premium (UP-FBS), and Endotoxin-Depleted (EDP-FBS)<\/li>\n<li>A widely used supplement for cell and tissue culture<\/li>\n<\/ul>\n","protected":false},"featured_media":125868,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[31,589],"product_tag":[647],"class_list":["post-58386","product","type-product","status-publish","has-post-thumbnail","product_cat-fetal-bovine-serum","product_cat-bovine-serums","product_tag-fetal-bovine-serum","entry","has-media","first","instock","taxable","shipping-taxable","purchasable","product-type-variable","has-default-attributes","has-rating","has-product-nav","col","span_1_of_4","owp-content-center","owp-thumbs-layout-horizontal","owp-btn-normal","owp-tabs-layout-horizontal","has-no-thumbnails"],"acf":[],"_links":{"self":[{"href":"https:\/\/purmabiologics.com\/blog\/wp-json\/wp\/v2\/product\/58386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/purmabiologics.com\/blog\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/purmabiologics.com\/blog\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/purmabiologics.com\/blog\/wp-json\/wp\/v2\/comments?post=58386"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/purmabiologics.com\/blog\/wp-json\/wp\/v2\/media\/125868"}],"wp:attachment":[{"href":"https:\/\/purmabiologics.com\/blog\/wp-json\/wp\/v2\/media?parent=58386"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/purmabiologics.com\/blog\/wp-json\/wp\/v2\/product_brand?post=58386"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/purmabiologics.com\/blog\/wp-json\/wp\/v2\/product_cat?post=58386"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/purmabiologics.com\/blog\/wp-json\/wp\/v2\/product_tag?post=58386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}