Bovine Calf Serum (BCS)
A cost-effective growth supplement used in labs worldwide for routine in vitro culture of many cell types.
- Supports growth of human embryo fibroblasts and hepatitis models
- Collected from calves less than 12 months old
- US-origin serum for general cell and tissue culture
- ✓Proudly made in the USA, manufactured in house
- ✓Certificate of Analysis available for every lot
- ✓Backed by decades of cell culture and protein biochemistry expertise
- ✓Bulk pricing, purchase orders, and custom formulations welcome
Description
Background
Laboratories around the globe use Bovine Calf Serum (BCS) to support the growth of many cell types in vitro. BCS provides proper growth for human Embryonic Fibroblast as well as models of hepatitis. Moreover, it performs well with U937 macrophage, human lymphocytes as well as blood cells including cord blood cells, T and B lymphocytes. We collect Bovine Calf Serum (BCS) from calves less than 12 months old.
Not sure which serum fits your cells? See our complete guide to cell culture serum.
Bovine Calf Serum (BCS) Vs. Fetal Bovine Serums (FBS)
- BCS contains approximately two-fold the protein compared to fetal bovine serum (FBS); among them are IgGs and other antibodies.
- Contains less growth factors than fetal bovine serum, however, it is proven to be adequate for the above-mentioned cell lines.
- Importantly, it is much more cost-effective than Fetal Bovine Serum (FBS).
Special Features
- PurMaTM Bovine Calf Serum (BCS) has US origin.
- PurMa TM Bovine Calf Serum (BCS) has been triple-filtered through 0.1 µM filters.
- PurMa Biologics sterilizes BCS with gamma irradiation methodology.
- PurMa Biologics performs heat-inactivation on our BCS.
- Has been tested for mycoplasma as well as endotoxin (see below), see the certificate of analysis.
- Has been tested on multiple cell lines, such as Hek293, COS1, and NS1 cells.
Analysis
For full Analysis performed on all PurMa Bovine and Horse Serums click here, as well as in “Documents” Tab: Routine Pathological Analysis on PurMa Bovine and Horse Serums
References
- Mitogenicity of fetal calf serum. Gergely et al. 1977;11(3-4):259-63. PMID: 311308
- Fetal Calf Serum Exerts an Inhibitory Effect on Replication of Duck Hepatitis A Virus Genotype 1 in Duck Embryo Fibroblast Cells. Wang, et al. Viruses. 2020 Jan 9;12(1):80. doi: 10.3390/v12010080. PMID: 31936491.
- Eicosanoid Content in Fetal Calf Serum Accounts for Reproducibility Challenges in Cell Culture. Niederstaetter et al. 2021 Jan 15;11(1):113. doi: 10.3390/biom11010113. PMID: 33467719.
| Methodology | Unit measured | Accepted level | Result |
| Sterility (Current USP and EP 2.6.1 for Bacteria & Fungi) | NA | Not Detected | Not Detected |
| pH | N/A | measured | 6.58 |
| Osmolality (USP 785) mOsm/KgH2 | mOsm/KgH20 | 280-340 | 288 |
| Hemoglobin (Fleming & Woolf) | mg/dL | <25 | 12.9 |
| Endotoxin (USP 85) | EU/mL | <20 | <0.100 |
| Mycoplasma (Barile & Kern; Large Volume, Direct Culture) | NA | Not Detected | Not Detected |
| IgG | Elliza | Measured | 0.19 ug/ml |
| Albumin | Eliza | Measured | ≤ 4.6 g/dL |
| Virus Testing (9 CFR 113.53c) | |||
| Bovine Adenovirus | NA | Not Detected | Not Detected |
| Bovine Parvovirus | NA | Not Detected | Not Detected |
| Bovine Respiratory Syncytial Virus | NA | Not Detected | Not Detected |
| Bovine Viral Diarrhea Virus | NA | Not Detected | Not Detected |
| Rabies | NA | Not Detected | Not Detected |
| Reovirus | NA | Not Detected | Not Detected |
| Cytopathogenic Agents (IBR) | NA | Not Detected | Not Detected |
| Hemadsorbing Agents (PI3) | NA | Not Detected | Not Detected |
| Bluetongue | NA | Not Detected | Not Detected |
Learn more: What Is Bovine Calf Serum?
Additional information
| Size | 1 x 50 ml, 1 x 500 ml |
|---|
Documents
Certificate of Analysis (COA): Available upon request for your specific order — email info@purmabiologics.com and we will send the current lot documentation.
Safety Data Sheet (SDS): Available upon request — email info@purmabiologics.com.
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