Description

Bovine Calf Serum (BCS)

Background

Laboratories around the globe use Bovine Calf Serum (BCS)  to support the growth of many cell types In vitro. BCS provides proper growth for human Embryo Fibroblast as well as models of hepatitis. Moreover, it performs well with U937 macrophage , Human lymphocytes as well as blood cells including cord blood cells, T and B lymphocytes  We collect  Bovine Calf Serum (BCS) from calves less than 12 months old.

Bovine Calf Serum (BCS) Vs. Fetal Bovine Serums (FBS)

1. BCS Contains approximately two folds protein compared to fetal bovine serum (FBS), among them, are Iggs and other antibodies.
2. Contains less growth factors than fetal bovine serum, however, is proven to be adequate for the above-mentioned cell lines.
3. Importantly, it is much more cost-effective than Fetal Bovine Serum (FBS).

Special Features

• PurMa^TM Bovine Calf Serum (BCS) has US  origin.
• PurMa ^TM Bovine Calf Serum (BCS) has been triple-filtered through 0.1 µM filters.
•  PurMa Biologics sterilizes BCS with  gamma irradiation methodology.
• PurMa Biologics  performs heat-inactivation on our BCS .
• Has been tested for mycoplasma as well as endotoxin (see below), see the certificate of analysis.
• Has been tested on multiple cell lines, such as Hek293, COS1, and NS1 cells.

Analysis

For full  Analysis  performed on all PurMa Bovine and Horse Serums click here , as well as in ” Documents” Tab: Routine Pathological Analysis on PurMa Bovine and Horse Serums

References

1. Mitogenicity of fetal calf serum. Gergely et al. 1977;11(3-4):259-63. PMID: 311308
2. Fetal Calf Serum Exerts an Inhibitory Effect on Replication of Duck Hepatitis A Virus Genotype 1 in Duck Embryo Fibroblast Cells. Wang, et al. Viruses. 2020 Jan 9;12(1):80. doi: 10.3390/v12010080. PMID: 31936491.
3. Eicosanoid Content in Fetal Calf Serum Accounts for Reproducibility Challenges in Cell Culture. Niederstaetter et al. 2021 Jan 15;11(1):113. doi: 10.3390/biom11010113. PMID: 33467719.